Best Vitamin B12 Supplements – 2023 Guide

Over 20 percent of Americans older than 50 are suffering from the effects of vitamin B12 deficiency. Developing countries such as Mexico, India and some African countries have even more people with this deficiency.

Vitamin B12 is necessary for your health. In order to maintain your brain’s health and protect your cognition, it is absolutely necessary you get the recommended amount of B12.

Both your cognitive and cardiovascular health require Vitamin B12, also known as cobalamin. Vitamin B12 aids your hemoglobin production, nerve strength improvement and homocysteine level regulation. Too much of homocysteine or amino acid produced by your body may escalate your risk of having a heart attack or stroke. Therefore, it is unquestionably necessary that your body expends the homocysteine in your blood.

According to WEBMD, Any pregnant woman who doesn’t have a diet including a sufficient amount of vitamin B12 is in danger of giving birth to a baby with a disabling or fatal defect.

Basically, people who lack enough meat in their diet are in danger of being deficient in Vitamin B12. It is, therefore, advisable that they supplement their diet with B12 capsules, shots and/or sprays. It is important that they make sure they’re getting the best type for their bodies. Currently, there are two types of vitamin B12 on the market:

Because this type is easier to produce and cheaper, it is the most popular. Once this type of vitamin B12 is introduced to your body, the Cyanocobalamin is converted into Methylcobalamin.

Since this type of vitamin B12 remains in your body longer, it is usually the recommended type of B12 supplement. This is the natural form of this vitamin, and for that reason your body doesn’t have to convert it to any other form.


Best Vitamin B12 Supplements – Comparison Table


Jarrow Formulas Methylcobalamin (Menthyl B12), Supports Brain Cells, 5000 mcg
Bioactive B12

Homocysteine Metabolism

Convenient Chewable Tablet
4.7 out of 5

Active B12 Lozenge with L-5-MTHF
Active B12 with L-5-MTHF


Great-tasting lozenge
4.7 out of 5

Pure Encapsulations – Methylcobalamin – Advanced Vitamin B12 for a Healthy Nervous System
Offers nervous system cutting-edge support

Promotes synthesis of protein

Healthy glutamate brain activity
4.7 out of 5

Thorne Research – Methylcobalamin (Menthyl B12) – Active Form of Vitamin B12 Capsules

Supports heart health and nerve function

Helps maintain normal circadian rhythms
4.7 out of 5

Life Extension Methylcobalamin 5mg, 60 Vegetarian Lozenges
Helps with homocysteine maintenance

The neurologically active form of vitamin B12

Helpful with energy in the body
4.7 out of 5

EZ Melts B12, 2,500 mcg, Dissolvable Vitamins, Vitamin B12 Supplement (90 Fast Melting Tablets)
Tablets are Vegan

Have no sugar, gluten-free,

4.7 out of 5

Go Nutrients Vitamin B12 Sublingual Liquid Drops – Methylcobalamin 3000 mcg
Increase Energy With B12 Liquid Drops:

Boost Memory And Lift Brain Fog

Easy And Convenient Liquid Drops
4.5 out of 5

Vitamin B12 Methylcobalamin – YOGABODY® Liquid Energy-B: Vegetarian & Vegan Liquid B12 Supplement
Pleasant and Sweet Taste

All Natural

Supplement is free of caffeine
4.5 out of 5

Fast Dissolving Sublingual Vitamin B12 Supplement with 2500 mcg Methylcobalamin by Vivid Health Nutrition

Vegan Safe

Fruit Punch Flavored


Jarrow Formulas Methylcobalamin (Menthyl B12), Supports Brain Cells, 5000 mcg

Not only does this vitamin B12 supplement support a person’s nervous system including his or her cognitive and mental health, it also promotes improved sleep. It is also an effective supplement capable of protecting a person’s cardiovascular health and supporting his or her energy.

This vitamin B12 supplement is available in a dissolvable or flavored chewable form. It is made with the methylcobalamin type of B12 which is the natural type of the vitamin that doesn’t have to be converted by the body.
Both forms of this vitamin B12 supplements are made by Jarrow Formulas. Jarrow markets all their products throughout the United States, Mexico, Canada and throughout the world.




Active B12 Lozenge with L-5-MTHF

Not only can you support your cognitive and cellular health with these Active B12 Lozenge, you can also increase your energy levels. Included with the lozenge is a methylfolate dosage that is essential to maintaining vitamin B12 healthy levels. You can easily break them in half or quarters to adjust your dosage.

These lozenges were sweetened naturally with cherry flavoring and xylitol and no preservatives, artificial flavors or colorants were used by Seeking Health. Users of these lozenges report that they dissolve very easily and created a significant energy increase. People with the MTHFR gene mutation also found this product suitable.

Each physician formulated B12 is fortified with folic acid, known as folate. When the two forms of vitamin B12 are used, various B12 benefits are provided.
Seeking Health vitamin B12 lozenges ingredients include 1000 mcg methylcobalamin, adenosylcobalamin and 800 mcg folate.




Pure Encapsulations – Methylcobalamin – Advanced Vitamin B12 for a Healthy Nervous System

As discussed above, Methylcobalamin has been found to be superior as a vitamin B12 supplement. The reasons Methylcobalamin is considered superior are:

• It delivers a better ability to support a person’s neurological function and healthy brain cell activity support.
• It also aids the maintenance of the healthy glutamate brain activity.
• It promotes synthesis of protein for maintenance of healthy nerve cells.
• It encourages emotional, cognitive, memory and nerve function.
• It also offers nervous system cutting-edge support.


These capsules are manufactured by Pure Encapsulations who are known to produce research-based, hypoallergenic dietary supplements. Only pure ingredients are used in their products. The results of using these pure ingredients are predictably for all patients’ benefit including the most sensitive.




Thorne Research – Methylcobalamin (Menthyl B12) – Active Form of Vitamin B12 Capsules

By having a technology platform of health diagnostics, the most up-to-date medical education and delivering premium science-based products, a standard for exceptional quality manufacturing was set by Thorne. With more than 350 products, Thorne has become the brand that most dispensed by 30 to 40 year old practitioners. Not only has Thorne increase the knowledge of wellness and nutritional health, they have been also dedicated to improving community health. By donating over $1M in profits and products, they have partnered with local charities and educational institutes.

Lubricants including magnesium stearate, binders, fillers and coatings could impair absorption of supplements, and for that reason none of Thorne products include them. They also follow the FDA’s Good Manufacturing Practices at the present time.

Features of Thorne’s Active Form of Vitamin B12 Capsules

• Since these capsules are an active form of vitamin B12, they are freely used by the body.
• Heart health and nerve function are supported by these capsules.
• Maintaining normal circadian rhythms is helped resulting in improved sleep.
• The body’s healthy methylation processes are supported by these B12 capsules.
• Colors, flavors, sweeteners and preservative are gotten from only natural sources. Gluten, artificial preservatives, wheat, stearates, rye, eggs, barley or nuts are never ingredients of Thorne products including the B12 capsules. There is no dairy, corn, soy, sugar, yeast, magnesium stearate or soy in this product.




Life Extension Methylcobalamin 5mg, 60 Vegetarian Lozenges

Vegetarians and people over 50 years of age often do not have an intake of enough vitamin B12 which is essential to be healthy. The form of vitamin B12 that is active in a person’s central nervous system is Methylcobalamin. It is a necessary component for cell replication and cell growth.

The common form of vitamin B12 supplements is cyanocobalamin, however, the liver of some people may not convert cyanocobalamin into sufficient amounts of methylcobalamin that a person’s body needs for suitable neuronal functioning. Healthy homocysteine levels can be maintained with methylcobalamin, and it will also accelerate nerve cell growth as well.

These Methylcobalamin capsules simply dissolve in your mouth.




EZ Melts B12, 2,500 mcg, Dissolvable Vitamins, Vitamin B12 Supplement (90 Fast Melting Tablets)

The EZ Melts Vitamin B12 is manufactured by Solara Labs. Solar Labs who are known for developing nutraceutical market’s exclusive and innovative delivery technologies. These tablets are both great tasting cherry flavored and fast-melting.

Features of EZ Melts Vitamin B12 Supplement

• A person’s mental clarity is supported by this bioactive for of vitamin B12.
• Energy levels and emotional balance are supported by this vitamin B12 supplement.
• Cell renewal is helped by B12 supplements resulting in healthy hair, skin and nails.
• Tablets made in the USA.
• Tablets are Vegan, have no sugar, gluten-free, are Non-GMO have natural sweeteners and natural flavors.




Go Nutrients Vitamin B12 Sublingual Liquid Drops – Methylcobalamin 3000 mcg

These Go Nutrients 3000 mcg methylcobalamin liquid drops are considered by many people to be the best way to supplement a person’s vitamin B12. Since the drops are a liquid form of methylcobalamin, they are absorbed quickly. Besides their quick absorption, they are also considered superior because of their being vegan. These drops are also capable of enhancing mood, sharpening focus, increasing energy and boosting metabolism of a person.

Far too often, people do not realize that not having enough B12 can cause fatigue, loss of energy, exhaustion, constipation, anemia, poor memory, depression, vision problems, nerve damage and digestive issues. All a person has to do to avoid these health problems is use these Go Nutrients vitamin B12 drops. By doing this a person’s can keep his or her body functioning with levels of high energy.

The manufacter of Go Nutrients liquid drops guarantees that these drops are 100% methylcobalamin. The drops no preservatives or artificial flavors and are non-GMO and kosher. They are also gluten free, 100% free of alcohol, soy free, wheat free, dairy free and sugar free.




Vitamin B12 Methylcobalamin – YOGABODY® Liquid Energy-B: Vegetarian & Vegan Liquid B12 Supplement

The vitamin B12 supplement made by YOGABODY contains the methylcobalamin form of B12 that is the same form found in a person’s body. Unlike most B12 supplements that are tablets, the YOGABODY are liquid drops. Liquid supplements of B12 are considered superior because the tablets made with binding agents may inflame a person’s digestive system. Since persons suffering from a B12 deficiency often have impaired digestion, it’s not a good idea to further inflame his or her digestive system that tablets may do.

In order to keep their bodies balanced, vitamin B12 supplements are essential for vegetarians. An easy and convenient way for them to get vitamin B12 is by using these drops that can be taken with a person anywhere. They can travel with you in your carry-on luggage since they are TSA approved.


Additional Features of YOGOBODY Vitamin B12 Supplements

• Pleasant and Sweet Taste: Cinnamon, beet roots and cranberries are used to flavor this vitamin B12 supplement. Ionic copper is the natural preservative of this supplement making it pure and clean.

• All Natural: This supplement is free of caffeine, soy, gluten, milk, sugar, salt, yeast, and/or wheat.

• 1 Year Guarantee: If you aren’t totally satisfied with this product, you can send it back for a full refund.




Fast Dissolving Sublingual Vitamin B12 Supplement with 2500 mcg Methylcobalamin by Vivid Health Nutrition

The job of your red blood cells is to deliver oxygen through your body. Playing a vital role, B12 both maintains and restores your red blood cells. B12 is essential to your body transforming food into cellular energy. When it converts carbohydrates into glucose, it decreases your fatigue and also helps to maintain a healthy nervous system. Designed for rapid absorption directly into your bloodstream, Vivid Health’s sublingual, high-potency formula holds 2,500 micrograms Methylcobalamin in each tablet.

Only the best non-GMO, all-natural raw materials are used by Vivid Health in the production of this product. This product is manufactured in the USA at a FDA approved facility.

The Vivid Health Vitamin B12 Supplement Is:

• Bioavailable
• Vegan Safe
• Fruit Punch Flavored
• Quickly dissolved under your tongue allowing fast absorption into your bloodstream
• A help to your maintaining healthy tissue growth and an aid to proper digestion vital to forming red blood cells
• Kosher




Great Source Nutrition Vitamin B12 Methylcobalamin 1000 mcg, 150 Tablets

A high quality Vitamin B12 supplement is offered by Great Source Nutrition. This product is a methylcobalamin form of B12 that is immediately active when absorbed. Many vegetarians and people over the age of 50 are in need of Vitamin B12 to boost their metabolism and support their digestive system. B12 is also an energy booster as well as support for a person’s cardiovascular system.


Features of Great Source Nutrition Vitamin B12 Supplement

• By helping your body to metabolize proteins, fats and carbohydrates into glucose, this B12 supplement will boost your energy.
• B12 helps your body to obtain healthy cholesterol levels keeping your heart healthy.
• Your mood is improved by the methyl B12 helping to stimulate your serotonin creation. Serotonin is a neurotransmitter whose job it is to support your mood.
• Aiding a person’s cognitive function and mental clarity the B12 vitamin supports memory.
• Great source Nutrition’s Vitamin B12 supplements are:
o Non-GMO
o Manufactured in a facility that is FDA approved
o Made up of only the ingredients on its label



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